6 Numerous interventions have been designed to reduce exposure to allergens in the environment where asthma patients live, work, learn, play, and sleep. Many common indoor inhalant allergens have been associated with increased risk of asthma exacerbations, including pollen, animal dander, house dust mites (HDM), mice, cockroaches, mold, and others. 5 Effectiveness of Indoor Inhalant Allergen ReductionĬontrol of environmental factors that may contribute to asthma is one of the four components of asthma management. While the severity of disease varies between patients and over time in the same patient, asthma can be fatal, accounting for approximately 1 death per 100,000 Americans.
For example, in 2012, asthma was one of the top twenty leading diagnosis groups for primary care visits and was the main reason for 1.8 million emergency department visits and 439,000 hospitalizations. 4 In the U.S., asthma contributes significantly to healthcare resource utilization and associated costs. Globally, asthma ranks 14th based on the burden of disease, as measured by disability adjusted life years. 2, 3 Asthma can significantly impact patients' and families' quality-of-life and ability to pursue activities such as school, work, and exercise.
1 In the United States (U.S.), the current prevalence of asthma has increased over the past decade, from an estimated 22.2 million Americans in 2005 to 24.0 million Americans in 2014. Bronchoconstriction, inflammatory cell infiltration, and airway edema reduce airflow intermittently, often in response to specific exposures, resulting in respiratory symptoms. Background and Objectives for the Systematic ReviewĪsthma is a chronic inflammatory disorder of the airways, characterized by varying degrees of airflow obstruction.
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